个人简历:
教育经历
| 2001 | 浙江大学分子生物学博士学位 |
| 1995 | 南京农业大学植物病理学学士学位 |
工作经历
| 2011- | 清华大学生命科学学院教授 |
| 2010-2011 | 北京生命科学研究所高级研究员 |
| 2006-2010 | 北京生命科学研究所研究员 |
| 2004-2006 | 美国冷泉港实验室博士后 |
| 2001-2004 | 美国俄亥俄州立大学博士后 |
主要科研领域及方向:
小分子RNA介导的RNA干扰 (RNA interference, RNAi) 是真核生物中的一种保守的基因表达调控机制。它在发育调控，抵抗病毒侵染，以及染色质修饰等诸多生物学过程中起到重要的作用。在植物中存在复杂的RNAi通路，其中包括miRNA介导的mRNA靶标切割或翻译抑制和siRNA介导的DNA和组蛋白甲基化进而引起转录水平的基因沉默。我们实验室综合遗传学，分子生物学，生物化学和生物信息学的方法，以拟南芥，水稻和衣藻为模式生物，研究中RNAi的作用机理和功能。我们的主要兴趣包括RNAi效应复合物的形成，小分子RNA如何识别和导致同源染色质的修饰，RNAi组分如何在不同通路中特异化，以及小分子RNA在拟南芥和衣藻生长发育过程中的作用。
代表论文:
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Ye, R., Wang, W., Iki, T., Liu, C., Wu, Y., Ishikawa M., Zhou, X., and Qi, Y. Cytoplasmic assembly and selective nuclear import of Arabidopsis ARGONAUTE4/siRNA complexes. Molecular Cell 46: 859-870，2012.2. Wei, W., Ba, Z., Gao, M., Wu, Y., Ma, Y., Amiard, S., White, C., Danielsen, J., Yang, Y., and Qi, Y. A role for small RNAs in DNA double-strand break repair. Cell 149:101-112，2012.3. Wu, L., Mao, L., and Qi, Y. Roles of DICER-LIKE and ARGPNAUTE proteins in TAS-derived small interfering RNA-triggered DNA methylation. Plant Physiology 160: 990-999，2012.4. Wang, W., Ye, R., Xin, Y., Feng, X., Li, C., Zhou, X., and Qi, Y. (2011). An Importin β protein negatively regulates microRNA activity in Arabidopsis. The Plant Cell, 23: 3565-3576. (Cover story).5. Wu, L., Zhou, H., Zhang, Q., Ni, F., Liu, C., and Qi, Y. (2010). DNA methylation mediated by a microRNA pathway. Molecular Cell, 38: 465-475 (Cover story). This work was featured in Cell, 141: 556, 2010.6. Wu, L., Zhang, Q., Zhou, H., Ni, F., Wu, X., and Qi, Y. (2009). Rice microRNA effector complexes and targets. The Plant Cell, 21: 3421-3435.7. Mi, S., Cai, T., Hu Y., Chen Y., Hodges E., Ni F., Wu L., Li S., Zhou H., Long C., Chen S., Hannon G., and Qi, Y. (2008) Sorting of small RNAs into Arabidopsis Argonaute complexes is directed by the 5’ terminal nucleotide. Cell, 133: 116-127. This work was featured in Cell 133:25-26, 2008.8. Zhao, T., Li, G., Mi, S., Li, S., Hannon, G., Wang, X.-J., and Qi, Y. (2007). A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes and Development, 29: 1190-1203. This work was featured in: Cell 129:1029, 2007; Genes and Development 21: 1153-1156, 2007; Nature 447: 5, 2007; Nature 447: 518, 2007; Nature Review Genetics 8: 406, 2007; ACS Chemical Biology 2: 436-437, 2007 .9. Qi, Y., He, X., Wang X-J., Kohany, O., Jurka, J. and Hannon, G. (2006) Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature, 443: 1008-1012.10. Qi, Y., Denli, A. and Hannon, G. (2005). Biochemical specialization within Arabidopsis RNA silencing pathways. Molecular Cell , 19: 421-428.
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