个人简历:
1995年 获北京中医药大学医学学士学位
1998年 获皖南医学院医学硕士学位
2001年 获北京中医药大学医学博士学位
2001.9-2009.11 清华大学 博士后、讲师、副研究员
2009至今 清华大学 教授
主要科研领域及方向:
网络药理学、生物信息学与中医药现代化,致力于网络药理学理论、方法,及其在中医药和肿瘤等疾病中的应用研究。发表论文100余篇,申请和授权中国、美国发明专利10余项。
代表论文:
Zhang B, Wang X, Li Y, Wu M, Wang S, Li S*. Matrine is identified as a novel macropinocytosis inducer by a network target approach. Frontiers in Pharmacology 2018;9;10:1-11
Guo Y, Nie Q, MacLean A, Li Y, Lei J*, Li S*. Multiscale modeling of inflammation-induced tumorigenesis reveals competing oncogenic and onco-protective roles for inflammation. Cancer Research 2017;77(22):6429-6441
Li S*. Mapping ancient remedies: applying a network approach to traditional Chinese medicine. Science 2015;350(6262 Supplement):S72-S74 (传统医学增刊)
Zu S, Chen T, Li S*. Global optimization-based inference of chemogenomic features from drug-target interactions. Bioinformatics 2015;31(15):2523-2529
Liang X, Li H, Li S*. A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-wei-di-huang Pill as a case study. Molecular BioSystems 2014,10(5):1014-1022 (Cover)
Zhao S, Li S*. A co-module approach for elucidating drug-disease associations and revealing their molecular basis. Bioinformatics 2012;28(7):955-961
Chen Y, Gu J, Li D, Li S*. Time-course network analysis reveals TNF-alpha can promote G1/S transition of cell cycle in vascular endothelial cells. Bioinformatics 2012;28(1):1-4
Li S*, Zhang B, Zhang NB. Network target for screening synergistic drug combinations with application to traditional Chinese medicine. BMC Systems Biology 2011;5(S1):S10
Zhao S, Li S*. Network-based relating pharmacological and genomic spaces for drug target identification. PLoS ONE 2010;5(7):e11764
Wu X, Jiang R, Zhang MQ, Li S*. Network-based global inference of human disease genes. Molecular Systems Biology 2008;4:189
Li S*, Zhang Z, Wu L, Zhang X, Li Y, Wang Y. Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Systems Biology 2007;1(1):51-60
Li S*, Wu LJ, Zhang ZQ. Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach. Bioinformatics 2006;22:2143-2150
联系方式:
清华大学自动化系
北京100084,中国
电话:+86-10-62797035
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个人主页:http://bioinfo.au.tsinghua.edu.cn/member/lishao/