颉伟

颉伟
颉伟 博士生导师 研究员

 

 

 

个人简历:       

1999-2003年,北京大学生命科学学院 生物科学 学士

2003-2008年,美国加州大学洛杉矶分校 分子生物学 博士

2006-2008年,美国加州大学洛杉矶分校 统计学 硕士

2008-2009年,美国加州大学洛杉矶分校 博士后

2009-2013年,美国圣地亚哥Ludwig肿瘤研究所,加州大学圣地亚哥分校 博士后

2013年-, 清华大学生命科学学院 研究员

主要科研领域及方向:

        研究兴趣包括表观遗传学,基因组学和生物信息学。运用高通量基因组学,同时利用分子生物学和计算生物学的方法,采用干湿实验结合的方式,研究干细胞分化和个体发育以及人类疾病中的表观遗传调控机制。本实验室将致力于:(1)干细胞分化过程中的组蛋白修饰和DNA甲基化介导的表观遗传调控(2)动物胚胎早期发育过程中的表观遗传调控(3)Cis-regulatory elements如启动子和增强子在细胞命运决定过程中的作用(4)表观遗传相关人类疾病的基因调控机理。

代表论文:   

Wei Xie#, Bing Ren# (2013) Enhancing Pluripotency and Lineage Specification, Science 341:245-7 (# Co-correspondence authors)

Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson,  Joseph R. Ecker, and Bing Ren (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells, Cell 153: 1134-1148.

Nisha Rajagopal, Wei Xie, David Hawkins, Sarit Klugman, Audrey Kim, Yan Li, Samantha Kuan, Lee Edsall, Wei Wang, Jason Ernst, Manolis Kellis, John Stamatoyannopoulos, Bing Ren (2013) A Random-Forest Based Algorithm for Prediction of Enhancers From Histone Modifications, PLoS Computational Biology 9, e1002968.

Wei Xie, Cathy L Barr, Audrey Kim, Feng Yue, Ah Young Lee, James Eubanks, Emma L Dempster and Bing Ren (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome, Cell 148: 816-831.

Tasuku Kitada, Thomas Schleker, Adam S. Sperling, Wei Xie, Susan M. Gasser and Michael Grunstein (2011) γH2A is a component of yeast heterochromatin required for telomere elongation, Cell Cycle 10 (2): 293-300.

Hao Wu, Volkan Coskun, Jifang Tao, Wei Xie, Weihong Ge, Kazuaki Yoshikawa, En Li, Yi Zhang and Yi Eve Sun (2010) Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes, Science 329 (5990): 444-448.

Mark H. Chin, Mike J. Mason, Wei Xie, Stefano Volinia, Mike Singer, Cory Peterson, Gayane Ambartsumyan, Otaren Aimiuwu, Laura Richter, Jin Zhang, Ivan Khvorostov, Vanessa Ott, Michael Grunstein, Neta Lavon, Nissim Benvenisty, Carlo M. Croce, Amander T. Clark, Tim Baxter, April D. Pyle, Mike A. Teitell, Matteo Pelegrini, Kathrin Plath and William E. Lowry (2009) Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures, Cell Stem Cell 5(1): 111-123.

Wei Xie, Chunying Song, Nicolas L. Young, Adam Sperling, Feng Xu, Rupa Sridharan, Anne Conway, Benjamin A. Garcia, Kathrin Plath, Amander Clark and Michael Grunstein (2009) Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells, Molecular Cell, 33(4):417-427.

Wei Sun*, Wei Xie*, Feng Xu, Michael Grunstein and Ker-Chau Li (2009) Dissect nucleosome free regions by a segmental semi-Markov model, PLoS ONE, 4(3):e4721(*Authors contributed equally).

Roberto Ferrari, Matteo Pellegrini, Gregory A. Horwitz, Wei Xie, Arnold J. Berk and Siavash K. Kurdistani (2008) Epigenetic reprogramming by adenovirus e1a, Science 321, 1086-1088.

Nimet Maherali*, Rupa Sridharan*, Wei Xie, Jochen Utikal, Sarah Eminli, Katrin Arnold, Matthias Stadtfeld, Robin Yachechko, Jason Tchieu, Rudolf Jaenisch, Kathrin Plath and Konrad Hochedlinger (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution, Cell Stem Cell, 1(1): 55-70 (*Authors contributed equally).

Feng Xu, Qiongyi Zhang, Kangling Zhang, Wei Xie and Michael Grunstein (2007) Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast, Molecular Cell, 27(6): 890-900.

联系方式: 

      +86-10-62771496 (Lab)

      +86-10-62771238 (Office)

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